The Greenville County region is among the most cost-effective options in South Carolina for assisted living at $2,800 monthly. The only city where care is cheaper is Sumter, which is about 160 miles to the southeast. Here, monthly rates are well below state and national averages at $2,200. In Spartanburg, care costs are considerably higher at $4,095, and in Florence, fees come in at $4,163. In the capital city of Columbia, care costs are on par with the national average, and in Myrtle Beach, seniors pay an average of $4,620 per month for this level of care. The most expensive city for assisted living is Hilton Head Island, where monthly rates come in at $5,475.