What Is Wearing-Off?

Wearing-off is when Parkinson's symptoms begin to reappear or become noticeably worse before it is time to take the next scheduled dose of medication. As wearing- off becomes more obvious, it may be harder to control the time when levodopa results in a good response ("on" time) and the time when there is a poor response to levodopa ("off" time).

It is important to be aware of the changes in symptoms that may indicate wearing-off. In this way, it may be possible to adjust therapy to provide better control of symptoms. As these changes take place, other unwanted drug-induced effects may also occur. These include involuntary movements such as dyskinesia (twisting, turning movements) or dystonia (abnormal positions and postures).


Maria M. Meyer, Paula Derr, and Susan Imke

Maria M. See full bio