What are the off label uses of Namenda?

2 answers | Last updated: Oct 10, 2016
Sunlight09 asked...

What are the off label uses of Namenda?

Community Answers

Sharron a answered...

Unlike most medications, Namenda has very few off-label uses. This is because Namenda has a very particular action in the body. Namenda (generic name is memantine) is used for the treatment of symptoms of moderate to severe Alzheimer's disease. Namenda also has an off-label use for the treatment of moderate to severe vascular dementia. According to the Health Professional's Drug Guide 2008, Namenda improves cognitive functioning in patients with Alzheimer's disease and mild to moderate dementia It is believed that the neuronal damage that leads to Alzheimer's disease is caused by intracellular calcium accumulation. Excess glutamate over-stimulates NMDA receptors in the brain, resulting in increased calcium movement into the neurons. Namenda blocks NMDA receptors, slowing intracellular accumulation and preventing further nerve damage. Namenda is classified as a NMDA receptor antagonist and as an anti-dementia agent.

A fellow caregiver answered...

Namenda actually has many off label uses and has been prescribed to treat patients with neuropathic pain such as neuropathy or trigeminal neuralgia, ADHD, traumatic brain injury, migraine prevention, aphasia, autistic symptoms including problems with speech, and social/behavioral impairments, coginitive decline related to psychiatric illnesses such as bipolar disorder, conduct disorders, and other affective disorders, as well as cognitive decline associated with parkinson's are just a few.

Namenda does not prevent the progression of pathology associated with Alzheimer's or other types of dementia, however can aid in cognitive ability and help with symptoms as the disease progresses, which help keep the patient functioning longer