My internal medicine doctor said methotrexate and plaquenil are helping her patients that have osteoarthritis (not rheumatoid arthritis). Are there any good studies that show these drugs do help osteoarthritis? The rheumatologist I had gone to said I should take plaquenil or methotrexate for inflammation in my arteries. Are there any good studies that show this is true? I do have a positive rheumatoid factor, but no joint erosions and my x-rays show I have osteoarthritis, not rheumatoid arthritis. My stomach can't take NSAIDS or aspirin and tylenol does nothing for the pain. The doctor wants me to only take one tramadol every other day. This is not adequate for my pain. What do you recommend for the pain?