What is gSAP, and what role does it play in Alzheimer's?
What role does gamma secretase activating protein (gSAP) play in Alzheimer's disease?
Beta-amyloid is a protein fragment that is believed to underlie most of the debilitating symptoms of Alzheimer's disease. It is produced in brain cells when a protein known as the amyloid precursor protein (APP) is cut by enzymes, called secretases. One of these is known as gamma-secretase. Researchers in the Laboratory of Dr. Paul Greengard discovered that gamma-secretase is activated by a protein they call the gamma-secretase activating protein (gSAP). In other words, gSAP stimulates gamma-secretase to make more beta-amyloid, which in the context of Alzheimer's disease may be bad because it could cause more beta-amyloid to accumulate in the brain.
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