What is the difference between the Exelon patch and the Aricept pill? 1 answer | Last updated: Nov 04, 2012 Jean C. Q Jean C. asked... What is the difference between the Exelon patch and the Aricept pill? My husband's dr. prescribed the patch and the insurance company denied it. He has now prescribed the pill. Answers Ladislav Volicer, M.D., Ph.D.Caring.com Expert A Ladislav Volicer, M.D., Ph.D., is recognized as an international expert on advanced dementia care. He is a courtesy full professor at the School of... See full bio 33% helpful Ladislav Volicer, M.D., Ph.D. answered... Exelon patch is causing less side effects than Exelon pill but has the same effect as Aricept pill. So you would not get much benefit except may be from easier administration. Recommended for You How to Find Alzheimer's Care Help Near You Best Organizations for Alzheimer's Support Seroquel and Alzheimer's Namenda and Aricept Can Aricept cause nastiness?