While not completely contraindicated (meaning it's not an absolute rule), there are many warnings about the use of Plavix with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.
risk is bleeding"”NSAIDs are known to cause ulcers and other disruptions of the gut, and Plavix works by inhibiting clotting. So a minor irritation of the lining of the stomach, which is often caused by NSAID use, can quickly become a dangerous bleed when the NSAID is coupled with Plavix.
Acetaminophen, known to most as Tylenol, is the preferred pain reliever for anyone on a "blood thinner" such as Coumadin or Plavix. As with all medications, be sure to let your doctor know what over-the-counter medications you are taking. If you need pain relief beyond that provided by acetaminophen, your doctor can suggest alternatives that are safer than using NSAIDs.