Dr. William J. Netzer, PhD, Research Associate
William J. Netzer, PhD is a Research Associate at the Laboratory of Molecular and Cellular Neuroscience and Fisher Center for Alzheimer's Disease Research at The Rockefeller University.
Dr. Netzer received his PhD in 1997 from Cornell University's School of Medical Sciences and began post doctoral study in the laboratory of Nobel laureate, Dr. Paul Greengard at The Rockefeller University in 1999. In 2000, he discovered that gamma-secretase, one of the principal enzymes necessary for beta-amyloid production, believed to be the primary cause of Alzheimer's disease, is dependent on the energy related molecule, ATP (adenosine triphosphate). He took advantage of this finding and in 2003 discovered that the anti-cancer drug, Gleevec (which was an ATP blocker) inhibits production of beta-amyloid. Published in Proceedings of the National Academy of Sciences.
In 2010, Dr. Netzer helped discover a protein, referred to as gSAP (gamma-secretase activating protein). This discovery has provided an understanding of how to control beta-amyloid production in Alzheimer's disease. gSAP is currently a major pharmaceutical target for the discovery of a new class of drugs for treating Alzheimer's. Published in Nature.