Parkinson's Disease: A Guide to Mind and Mood

How Parkinson's can change a person's mood, thinking, and behavior
All Rights Reserved

Quick summary

Some of  the most profound consequences of Parkinson's disease may result not from motor symptoms, but from psychiatric and behavioral difficulties. These problems often go unrecognized and untreated. Here's what to watch for.

Changes in mood, thinking, and behavior

Many family caregivers don't realize that some of the most stressful challenges of Parkinson's can come from changes in a patient's mood, thinking, and behavior. For instance, depression, dementia, and drug-induced psychosis are potentially crippling conditions that often accompany Parkinson's. Yet doctors and researchers haven't paid much attention to such troubles.

"If the patients do mention it" -- and, typically, they don't -- "it kind of gets shoved to the side by the issues that are more interesting to the doctor rather than to the patient," says neurologist Joseph Friedman, director of the Parkinson's Disease and Movement Disorders Center at NeuroHealth in Warwick, Rhode Island, and author of Making the Connection Between Brain and Behavior: Coping with Parkinson's Disease .

Not every Parkinson's patient experiences the problems listed below, but if you notice any of them in the person you're caring for, tell his neurologist or nurse. Some of the difficulties can be relieved by adjusting Parkinson's drug dosages or giving other standard treatments. Be sure to ask about potential side effects, some of which may worsen certain Parkinson's symptoms.

Depression and anxiety

Sad or hopeless feelings

About 40 to 50 percent of people with Parkinson's develop depression. Usually it's mild to moderate in intensity, but roughly 5 to 10 percent of cases are the more severe form known as major depression. Evidence suggests that depression results partly from neurochemical changes in the brain caused by the Parkinson's disease process -- it's not just a psychological reaction to having the illness.

Diagnosing depression in a person with Parkinson's disease can be complicated, because the two disorders share many symptoms: fatigue, loss of pleasure or interest in normal activities, problems with sleep, slowness of movement, lack of facial animation. Parkinson's patients may look sad even when they're not, because on top of having stiff facial muscles, they speak softly and don't respond quickly.

To correctly identify the mood disorder, doctors look for distinguishing clues such as sustained feelings of sadness, worthlessness, guilt, or irritability. Depression can be treated with psychotherapy and drugs, such as selective serotonin reuptake inhibitor (SSRI) drugs or tricyclic antidepressants. In severe cases, electroconvulsive therapy may be considered.


About 40 percent of Parkinson's disease patients struggle with anxiety, often in tandem with depression. So-called generalized anxiety makes individuals so worried and edgy that they can't sleep or they experience a racing heartbeat, shortness of breath, and sweating. Such symptoms can be provoked by distress and embarrassment over how others may react to seeing their Parkinson's tremor or shuffling gait, and the problem can hurt their ability to perform at work or enjoy social gatherings. Even worse, anxiety itself can aggravate Parkinson's motor symptoms.

People with Parkinson's also often suffer anxiety when their levodopa or dopamine agonist drugs start wearing off. They fear that the next dose won't control their symptoms again, or that they'll be stranded out in public, unable to move well. Extreme anxiety can produce scary panic attacks that leave the patient unable to breathe and feeling as if he's having a heart attack. For some, social situations provoke such an intense bout of nerves that they develop a social phobia and shun any gatherings.

Anxiety disorders can be allayed with SSRI antidepressants or antianxiety drugs such as Valium.

Fatigue and dementia

Feeling tired, unmotivated, or less sharp

About half of people with Parkinson's disease complain of fatigue. Some feel sleepy, whereas others report low energy or an exhaustion that levels them. Doctors will explore to what extent the symptoms result from depression or sleep problems; addressing those disorders may relieve the fatigue. Exercise may also help, so Friedman encourages patients to slowly work up to a regular walking routine of 30 minutes a day. If fatigue still persists, he sometimes prescribes stimulants.

As Parkinson's disease becomes an ever-greater obstacle to everyday routines, roughly 40 percent of patients exhibit apathy. They lose interest and joy in the hobbies or activities that used to bring them pleasure, and they seem indifferent to the friends, family, and events around them. They stop caring about anything.This can be upsetting to see in a patient, especially because it seems as if he's giving up on treatment and on life. Then again, apathy may protect him from distress and frustration over his growing disability, Friedman points out. Apathy may be related to depression, dementia, or sleep disorders, so addressing those conditions may help. Generally, however, there's no good cure for apathy.

Most people with Parkinson's disease will at some point experience mild cognitive changes that may hinder attention, memory, mental processing speed, problem-solving, processing of visual information, and the ability to pull the right words from one's vocabulary. In many cases, patients compensate for these subtle deficits without much detriment to life at work or home.

Showing signs of dementia

Severe impairment of memory and thinking, along with confusion and disorie ntation, may develop with dementia, the worst of the nonmotor Parkinson's symptoms. It can render the patient incapable of taking on daily activities of living. Although research studies vary widely on the numbers, experts generally estimate that 30 percent of Parkinson's patients suffer from dementia.

Usually, dementia arises in later stages of Parkinson's. If major cognitive trouble arises early, another illness is likely to blame, such as Alzheimer's disease or a Parkinson-like disorder called dementia with Lewy bodies (which actually looks similar to very late-stage Parkinson's dementia).

The dementia of Parkinson's disease is somewhat different from that of Alzheimer's, although there are similarities, says Friedman. Alzheimer's patients don't record new memories and wouldn't remember a grocery list of five items. People with Parkinson's dementia would store the memory of the items but may not recall them until you give hints or cues. Patients struggle more with language and forgetting of words and names in Alzheimer's than in Parkinson's. On the other hand, Parkinson's dementia patients are, earlier on, "very bad at judging spatial relationships between objects, which can be a problem with their driving," Friedman says. "They have trouble organizing, they have trouble multitasking."

The Alzheimer's drug Exelon (rivastigmine) was federally approved for treating dementia in Parkinson's in 2006, but its benefits are relatively modest, says Friedman. The same appears true of other Alzheimer's drugs in the same category, called cholinesterase inhibitors.

Sees things that aren't there or experiences paranoia

Hallucinations and paranoia

Hallucinations are a side effect in about 30 percent of people taking Parkinson's drugs -- particularly dopamine agonists -- and they usually occur only after many years. The problem is more likely to arise in patients with dementia. A symptom of psychosis, the hallucinations are often benign at first, involving visions of children, strangers, or animals around the home. Usually, a Parkinson's patient realizes the episodes aren't real but may not tell anybody about them for fear that he's losing his mind.

Parkinson's drugs may also trigger serious psychosis, in which people can't tell what's real and what's not. About 5 to 10 percent of people with Parkinson's disease get caught up in delusions (false or illogical beliefs) and paranoia -- such as becoming convinced that others are spying on them. The most common delusion, says Friedman, is that the patient's spouse is having an extramarital affair. Such distressing psychotic symptoms can make the patient extremely difficult to care for, and they're a major factor leading to placements in nursing homes.

To treat hallucinations and delusions, doctors switch or try to reduce the Parkinson's medicine -- but the catch-22 is that the pills are crucial for controlling the patient's motor problems. Physicians may prescribe atypical antipsychotic drugs such as Seroquel (quetiapine) or Clozaril (clozapine).

Sleep problems

It's common for people with Parkinson's disease to complain of excessive drowsiness during the day. Several factors are to blame. One is that, for various reasons, most Parkinson's patients don't get enough sleep at night. When levodopa or dopamine agonists wear off in the nighttime, symptoms of stiffness, tremor, and slowness of movement resurface, says Kelly Lyons, a research associate professor of neurology at the University of Kansas Medical Center in Kansas City. A severe tremor might wake the person, as might stiffness as he tries turning over in bed. Or discomfort may keep him from falling asleep to begin with.

Another complication is that Parkinson's patients tend to suffer from sleep disorders, including:

* Sleep apnea -- interrupted breathing episodes during slumber
* Periodic limb movements -- repeated jerking motions of the legs while asleep
* Restless leg syndrome -- uncomfortable tingling or crawling sensations in the legs, causing an irresistible urge to move them during sleep
* REM sleep behavior disorder -- "acting out" of vivid dreams, sometimes leading to punching or kicking of bed partners

What's more, studies show that Parkinson's drugs have sedative effects, says Lyons. The challenge is to try adjusting the medication dose or scheduling, or switching to another drug, while still keeping motor symptoms well controlled. Other medicines prescribed for anxiety, depression, and psychosis can also cause daytime sleepiness. Altogether, Lyons says, "the whole sleep cycle is just really messed up" for the Parkinson's patient.

Compulsive behavior

Secret gambling or other compulsive behavior

Use of Parkinson's drugs, particularly dopamine agonists such as Mirapex (pramipexole), has on occasion led to uncontrollable gambling, shopping, or preoccupations with sex, or to obsessive repetition of certain activitie s such as collecting or counting particular objects. Reducing or changing medication may resolve the problem.

For more information online:

Download Parkinson Disease: Mind, Mood, and Memory, a comprehensive brochure from the National Parkinson Foundation's free publications page.

Search for information on depression and anxiety at the National Institute of Mental Health's publications page .

Check out the Parkinson's Disease Foundation's fact sheet, "Coping With Dementia: Advice for Caregivers" .

Ingfei Chen

Ingfei Chen has witnessed the hope and hype and miracles and failings of medical care and scientific research during more than 15 years of covering both areas as a journalist. See full bio

8 months, said...

My husband was diagnosed a year and half ago and will be 57 December 18. His right hand shakes. However, I am noticing irritablity and I am feeling he is trying to control me. He is also having problems at his work, telling people off etc. He wants to make it to 62 and then retire as a Boeing manager. That is 5 years away and as fast as his personality is changing, I am not sure he can work until he is 62.

over 1 year, said...

Husband diagnosed 2 years ago. Seeing more cognitive and personality changes. Finding my thoughts of the future scary and overwhelming.

over 1 year, said...

I was diagnosed with Parkinson's disease 3 year ago at the age of 69. For several months I had noticed tremors in my right hand and the shaking of my right foot when sitting, as the disease progressed i totally lost balance. Neurologist had me walk down the hall and said I didn't swing my right arm. I had never noticed! I was in denial for a while as there is no history in my family. I used amantadine, Carbidopa/levodopa and physical therapy to strenghten muscles all failed. In 2016 a friend suggested Newife Heral Clinic who have successful heral treatment for Parkinson's disease, i contacted the heral clinic via their website and purchased the Parkinson's disease herbal supplement, i used the herbs for 7 weeks and my symptoms were reveresed. Its been 6 months no sign of parkinson's disease, contact this herbal clinic via their email (newlifeherbal @ gmail. com) or visit their website (www. newlifeherbalclinic. weebly. com)

over 2 years, said...

Hello all!

over 2 years, said...

I have recently been diagnosed with PD. I'm just trying to get a handle on what I'm facing. I am only on one medicine right now and hope to stay that way. I'm 50 and wonder if changing diet or how you source food has helped anyone? This has helped me already. I wondered if my "technology irritation" could be a part of PD. I used to work in the field.

about 4 years, said...

My husband has had PD for nearly 20 years. It affects mostly motivation, sleep, processing and short term memory. The apathy seems to now be combined with or moving to "demands", and what he feels he needs or wants. I work full time and feel tremendously stretched. I don't know how to talk with his doctor about some of the problems.

over 4 years, said...

Hello, my husband was diagnosed with PD just over two years ago when his first 'motor' symptoms became apparent. However for some time before that at least six years his mood, most angry outbursts, began but were put down to other tings that were happening in his life tat he was coping with. He seems in some ways now such a different person, character - has anyone else exoerienced something similar with their partner / parent. Anya

over 5 years, said...

I wish my Physician and the Medical doctor could see this. Severe signs have happened and still are. Memory loss, angering and disturbing issues, etc. It all fits.

over 5 years, said...

I need much more information on this! I am Bi-Polar but I had my first ever bout of depression recently - didn't even want to change chothes/bathe/brush teeth. This from a woman who owned a medical computer company before for 28 years! Also, I started a new company and purchased over $45,000 in inventory! LOL! The good news is, it is already hitting a break-even point after 11 months (again, thank you Mr. Mania). Typing this, I realize your answer "Get yourself to a psyc., Girl). I will do that monday. I would like to see this addressed more at length though! Thank you. Your articles help me a lot. FYI, I have MSA, Parkinsons and Dystonia. So not only am I going to die, but I am going to walk funny until I do!!! Also, SPEACH THERAPY has helped prolong my life unbelievably! I wish others understood how life changing it can be! C.

over 5 years, said...

There is no "set symptoms" that are displayed by a PWP (person with Parkinsons). Many of the symptoms are actually "reactions to medications". There are many different medications, along with "combinations" of different medications.....Then it depends on a person's own personal "system" as to how their body will "react" to the meds......If this isn't "challenging enough" also depends on the strength, or "dose" of the medication.(As the dosage amount may vary from person to person.) There is a site called "" that will help in the understanding of person's with Parkinson's Disease, and there "Caregivers." This site is a "blog, questions and answer" site for all you would have to register for the "Parkinson Community".

over 5 years, said...

My husband was diagnosed with PD in 2003. It's the non-motor symptoms that are straining our marriage, the incomprehensible speech; the word-finding difficulties; the blank face; the monotone voice; sometimes it's serious hallucinations and delusions. Sometimes it's too much for me. Let's be strong for each other.

over 6 years, said...

@ donnamills47 ~ The first thing I thought of was that with all those meds his body is toxic. Maybe you could look into that also and see if something can be done to reduce the toxins. Ethelle at

over 6 years, said...

@ momjob2 ~ I really enjoyed reading your post. You reminded me of how important it is to take time to listen. Here's a poem I like that a friend of mine has written. I think it expresses what you are saying in your post. The author is Norman McNamara from the Uk who was diagnosed with Lewy's Bodies after originally having a diagnosis of Alzheimers. Hear My Voice Will someone please hear my voice? I have dementia, though not by choice, My days and nights pass me by, Will someone out there hear my cry? Inside this body, I'm still me, Speak to me and you will see, I have thoughts, I have a heart, To listen to me, would be a start, Yes it's true, I do forget, The months, the days, the time that's set, But if you listen, you will hear, About my life, what I hold dear, And I will tell you of my life, That did not end with Dementia`s Strife, I still have, so much to do, Hear my voice, and you will too Stay strong, Ethelle at

over 6 years, said...

@ Dove Eyes from Tenn. ~ I suggest you contact the Alzheimer's Association free number and talk with a counselor. Do not go another day without calling this number as they will help you to make sense of what is going on with Kenneth: 1-800- 272-3900. The line is open 7 days a week and 24 hours a day so you can call even in the middle of the night. Good luck to you and stay strong. Ethelle

over 6 years, said...

My husband was tested for Parkinson's soon after his diagnosis of vascular Alzheimer's. I find the symptoms overlaping between the two conditions. I'm curious to know if the symptoms listed in this article are listed in order as they first appear in the individual? Ethelle

over 6 years, said...

My husband was diagnosed with Parkinson's in 2004 and has had moderate physical problems, mostly tremor. However he has always had significant sleep issues as well as depression, anxiety and apathy but it was only recently that we found a neurologist who actually was willing to focus on these non-motor issues. Also at this point his physical problems seem to have decreased and the non-motor issues are a much larger problem. It is wonderful to see this now being recognized as part of Parkinson's disease and taken seriously. Thank you.

almost 7 years, said...

Its very informative article

almost 7 years, said...

My friend is having some problem and i think he is going in early stage of PD. i sow his hands shaky several times and now he is complaining of muacle pain on his upper leg. he had a fall once.he never talked about i think he is trying to hide it. As a good frend i a so worry and i wanted to help him and i don't know how?