Plavix(http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000040) is a medication used to inhibit the formation of potentially harmful clots. Coumadin(http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000634) is a medication that is designed to prevent the formation of potentially harmful clots. The primary
difference is in how they work towards preventing clots from forming. Coumadin works by reducing the ability of an enzyme to recyle Vitamin K which in turn results in a marked decrease in the ability of the blood to coagulate. Plavix works by inhibiting a receptor on the cell walls of platelet membranes that triggers coagulation. While both drugs have drug interactions Coumadin is particularly difficult to work around with other medications.