The main difference between narcolepsy and epilepsy, is that narcolepsy is affiliated with sleep, while epilepsy is affiliated with seizures. With narcolepsy, one may fall asleep at any time, sometimes in the most inopportune moments, like a conversation. After be woken up, the person often feels refreshed. Epilepsy is a series neurological disorders, which is characterized by unprovoked seizures. The symptoms of epilepsy and narcolepsy can be reduced by medication, but there is currently no cure for either. Narcolepsy, is often a symptom of epilepsy.