The chemotherapy regimen for Hodgkin Disease known as MOPP does have several effects on long-term health but danger to the cardiovascular system isn't one of them. MOPP causes permanent sterility due to the Mustargen (the "M" in MOPP). It also has a 3 percent chance of leading to a secondary cancer, acute myelogenous leukemia. For this reason many oncologists choose an alternative chemotherapy regimen, ABVD, for Hodgkin disease when possible. Radiation treatment to the chest carries a risk of damage to the cardiovascular system, but the MOPP chemotherapy regimen should not.