Surgery could be safe while on Humira, the most common side effect is infection from the surgery. A lot of doctors ask their patents to skip the dose prior to surgery, and not take any Humira for two weeks. If they do, you will not want to take any Humira prior to the next two weeks after surgery.However, there is no clear answers form the clinical studies. Thus, it is rather a opinion from your doctor than from information supported from research. Hopefully, this gets you past the pneumonias and wound infections that are the most common post-surgical infections.