Without any insurance, you would end up paying around $100 to $200 for the Humira pen. With insurance, the price can decrease significantly depending on the type of coverage you have and how much your insurance company covers. When you run out, you can get your prescription for this replaced, you just have to make sure you don't overdose on the product. The price will remain the same as long as you don't have to replace the product too often, then the price can start to really add up with time. The average paid per month will differ from person to person.