That depends on which Advair you have. For the Advair Diskus which comes as 100/50, 250/50, or 500/50 doses, there are usually 60 puffs. There are also Advair HFA inhalers, which contain 120 metered inhalations. The Advair Diskus inhalers have not been approved for more than twice daily use. Each of these types of inhalers may have a few extra puffs in them (this is due to occasionally having to "prime" the pump, especially with the HFA inhalers). There are Advair Diskus inhalers available with fewer puffs (30), so be sure to check your packaging to see which one you have. For twice daily dosing, you should have 60 puffs available in your diskus.