This really depends on your body's ability to get rid of the drug. If every thing in your body is normal kidney and liver function, levaquin should be eliminated from your body in about 32 - 40 hours. If you take one dose daily. and if you use half-life it would take about 6-8 hours to a person that has every thing normal. It wouldn't hurt if you ask your doctor how long and if your body is functioning as it should and if you are allergic or any of that type of thing before taking this medication can be helpful. You might also want to do some research on any other questions that you might have regarding this medication or any other medication.