In some cases there is a chance for Lipitor to cause impotence. It really depends on the person and how they react to medication whether or not they will develop impotence from Lipitor. Unfortunately, impotence is a very common occurrence of Lipitor and has been known to happen to many men. If a man is experiencing impotence while taking Lipitor they should immediately consult their doctor. Even though it may be embarrassing for a man to talk to their doctor they should definitely consider it. Once their doctor knows about the issue they may know what to do to stop the problem from occurring at all.