Actonel, the bone loss prevention drug, has indeed been shown to have side effects that consist of joint, muscle and bone pain. The pain can possibly affect anywhere from your jaw to yes, your leg. This drug does a long list of common to rare side effects. In addition to joint and muscle pains, the user may experience back pain, stomach cramps, neck pains and chest pains. Actonel is also not recommended for people who are unable to sit or stand for at least 30 min.