There is a potentially very dangerous interaction between the drugs Abilify and Topamax. Like a lot of other times when you mix up medications, there may be side effects, but
this combination can be dangerous. According to drugs.com, this combination of drugs may result in the person's ability to regulate their own body temperature. To read more, visit drugs.com. To specifically answer the question, no it is not a guarantee that these medications can be taken together 100% safely. In this case, the side effects can lead to a serious problem. However, it is up to the patient whether or not the need for both medications simultaneously outweighs the possible side effects, but I believe in this case the risk is too great.