The short answer: no. Lymphoma is a malignant transformation of cells in your lymph tissue. Essentially, it is a cancer of your lymph nodes. Risk factors for lymphoma include HIV
infection, immunosuppression, infection with the EBV virus, infection with the HTLV-1 virus, infection with the bacteria H. pylori, and autoimmune disease. Certain congenital diseases can also put you at risk for developing lymphoma. The development of lymphoma could also be idiopathic, meaning that no good reason can be found for why lymphoma develops. A total knee replacement is a common surgery; the most common reason for knee replacement is arthritis that has progressed to the point that medications don't relieve the pain. Although a knee replacement could put you at increased risk for hemorrhage or infection, it does not put you at increased risk for lymphoma.