There can be signs of bone cancer present in blood work. When a bone is growing, healing from being broken, or more bone is produced as an affect of disease there is a higher concentration of an enzyme known as alkaline phosphatase. These high levels, however, are also present in growing children and people healing from broken bones, so it is not considered to be a reliable test. Low levels of the protein hormone made by the parathyroid gland may also indicate the presence of bone cancer. High blood levels of phosphorus can be another sign of bone cancer. Another test can measure the amount of calcium in the blood. High calcium levels can indicate bone cancer as well.