Do blood clots run in families? 1 answer | Last updated: Oct 02, 2010 Locavore Q Locavore asked... Do blood clots run in families? Answers MalindaF42 A MalindaF42 answered... Blood clots do not run in families. However some family have genes that will make a person more prone to develop them. Usually doctors will order tests if they suspect a person is at risk. Recommended for You Can blood clots caused by breast cancer treatment be dissolved?