Pruritis: What Itchiness Without Rash Might Mean
What it means: Feeling itchy in more than one specific spot can have many causes, but when there's no accompanying visible skin change, it may be pruritis, one of the first symptoms of lymphoma (cancer of the lymph system). In fact, it's known as the "Hodgkin itch" (the two main types of lymphoma being Hodgkin's disease and non-Hodgkin's lymphoma).
More clues: The itchiness is more intense than that caused by ordinary dry skin. It can be felt generally or, most commonly, in the lower legs. Less often, the skin also looks reddish and inflamed. Another common symptom of both Hodgkin's disease and non-Hodgkin's lymphoma is swelling of the lymph nodes in the neck, armpit, collarbone, or groin. (Note that lymph nodes can swell because of common infections as well.)
What to do: Report persistent, intense itching to your doctor.