Mixing alcohol with medications
There are plenty of drugs that come with that cute bright orange warning sticker attached, telling you not to drink when taking them. However, the sticker can fall off, or not get attached in the first place, or you might just really need that cocktail and figure it'll be OK "just this once." But alcohol, combined with a long list of painkillers, sedatives, and other medications, becomes a deadly poison in these situations. In fact, many experts now say you shouldn't drink when on any medication without first checking with your doctor.
Alcohol can also have a dangerous interaction with OTC drugs such as diphenhydramine (Benadryl) and cough and cold medicines -- and if the cough or cold medicines themselves contain alcohol, you can end up with alcohol poisoning. Alcohol can also compete with certain medications for absorption, leading to dangerous interactions. Mix alcohol and certain antidepressants, for example, and you have the potential for a dangerous rise in blood pressure, while alcohol and certain sedatives such as Ativan or Valium can depress the heart rate enough to put you in a coma.
How to avoid it: When you get a new prescription, ask your doctor or a pharmacist if the medication is safe to take while drinking alcohol. If you're a heavy drinker and you know it's likely you'll drink while taking the medication, tell your doctor. She may need to prescribe something else instead. Also, read the handouts that come with your prescriptions to see if alcohol is mentioned as a risk. And read the labels of all OTC medications carefully, both to see if alcohol is mentioned as a risk and also to see if alcohol is an ingredient in the medication itself.

