- When you pick her up for an appointment, is she routinely not ready yet?
- Does she forget you said you'd be visiting and seem surprised to see you?
- Does she berate you for being late when you're not?
- Does she no longer mention certain old friends, or when you mention them, is she dismissive?
- Has she quit longstanding social engagements (clubs, card parties, religious committees)?
- Has she noticeably lost interest in younger grandchildren (she's no longer asking about them, wanting to spend time with them, or sending them notes or gifts)?
A shrinking social life and increased isolation is not a natural function of aging. Unless she's so old that her longtime friends have all moved or died, it's more likely that she's withdrawing because of embarrassment about her dementia or inability to keep up -- or her friends are dropping her because of their own discomfort. Social appointments may also dwindle as her concept of time grows muddied. A person with Alzheimer's or other forms of dementia may forget meetings, anticipate them at the wrong time, and also lose track of recent acquaintances.

