Addison's Disease Symptoms: What Dark Red Lines on Your Palm Might Mean
What it means: A palm-reading mystic might have her own interpretation, but to a physician, a deepening of the pigment in the creases of the palms or soles is a symptom of adrenal insufficiency, an endocrine disorder. Also known as Addison's disease, the name comes from its discoverer, physician Thomas Addison. Its two most famous victims include President John F. Kennedy and -- it's thought -- the writer Jane Austen.
More clues: Hyperpigmentation may also be visible around other skin folds, scars, lips, and pressure points (knees, knuckles). Addison's sufferers have low blood pressure, which falls further when the person stands. Salt loss can lead to a craving for salty food. The disease affects men and women equally but is found most commonly between ages 30 and 50.
What to do: It's important to mention this visible symptom to a doctor, as skin changes may be the first symptoms seen before an acute attack (pain, vomiting, dehydration, and loss of consciousness, a cascade known as an Addisonian crisis). Lab tests to measure cortisol (which is produced by the adrenal gland) provide a diagnosis.